Top Premarket Decliners

07:43 AM EDT, 09/18/2026 (MT Newswires) -- Xenon Pharmaceuticals (XENE) shares were down nearly 26% in premarket trading Friday after the company paused enrollment of new patients in studies for major depressive disorder and bipolar depression. Digital Currency X Technology (DCX) stock was more than 19% lower following a 38% rise in Thursday's session. ALX Oncology (ALXO) stock was 8% lower, extending the 1% loss from Thursday's session. Stewards (SWRD) shares were down 8%, partially reversing the 18% rise at the prior close. Hotel101 Global (HBNB) stock was 7% lower following a 0.9% advance.